IRP4, Biomaterials design for biomedical engineering succeeded to implement a multidisciplinarity approach (MSE, biology, physics, mechanics) through four actions funded in 2016 and used to investigate the design, fabrication and use of architectured biomaterials for biomedical engineering. For 2020-2025, in line with the continued effort to strengthen IRP4, we will keep promoting these interdisciplinary scientific themes and introduce a new research topic:
Microenvironments for biophysics and tissue/disease models. This research aims at engineering innovative architectured microenvironments and 3D scaffolds that mimic living tissues to (i) study fundamental biology of cells and tissues and (ii) investigate human diseases and potential therapies in vitro.
Biomaterials for tissue regeneration (bone, muscle, soft tissue,…) and medical devices (prostheses, orthoses,…). We continue developing and valorizing biomaterials for accelerating and enhancing functional recovery after surgery, cancer, or in malformation’s treatments.
Multi-scale characterization of biomaterials and tissues/organs. We seek to promote the development and use of appropriate techniques for characterizing biomaterials, living tissues and their interface, either in- or ex-vivo, such as mechanical testing and modeling, tomography or microscopy.
Architectures of nanomaterials for biosensors. Based on an emerging expertise of the different partners, this new research theme aims at architecturing nanomaterials to obtain nanowire networks for label-free detection of biomolecules (e.g. DNA, proteins).
IRP4 - CellArchitecture: Artchitecture-inspired multicellular organization of epithelial cells.
IRP4 - Characterization: Left: qsSAXSI image of mineral nanoparticules in the biopsy of an iliac crest of a sheep. Right: ACOM-TEM image of the crystallographic orientation of bone mineral nanoparticles from bovine femur cortical.
Vascular implant made of NiTi knitted fabric inserted in a silicone elastomer.